1. Valerio A, D'Antona G, Nisoli E. Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective. Aging (Albany NY). 2011 May;3(5):464-78.

2. D'Antona G, Ragni M, Cardile A, et al. Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab. 2010 October;12(4):362-72.

3. Alvers AL, Fishwick LK, Wood MS, Hu D, Chung HS, Dunn WA, and Aris JP. Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell. 2009;8:353-69.

4. Fuchs S, Bundy JG, Davies SK, Viney JM, Swire JS, and Leroi AM. A metabolic signature of long life in Caenorhabditis elegans. BMC Biol. 2010;8:14.

5. Yalçin AS. Emerging therapeutic potential of whey proteins and peptides. Curr Pharm Des. 2006;12(13):1637-43.

6. Krissansen GW. Emerging health properties of whey proteins and their clinical implications. J Am Coll Nutr. Dec. 2007;26(6):713S-23S.

7. Kent KD, Harper WJ, Bomser JA. Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death 
in human prostate epithelial cells. Toxicol In Vitro. 2003 Feb;17(1):27-33.

8. Bounous G, Gervais F, Amer V, Batist G, Gold P. The influence of dietary whey protein on tissue glutathione and the 
diseases of aging. Clin Invest Med. 1989;12:343-9.

9. Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother. 2003 May- 

10. Katsanos CS, Chinkes DL, Paddon-Jones D, Zhang XJ, Aarsland A, Wolfe RR. Whey protein ingestion in elderly persons 
results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res. 2008 Oct;28(10):651-8.

11. Bounous G, Batist G, Gold P. Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin Invest 
Med. 1989 Jun;12(3):154-61.

12. Currais A, Maher P. Functional consequences of age-dependent changes in glutathione status in the brain. Antioxid 
Redox Signal. 2013 Feb 5. [Epub ahead of print]

13. Shertzer HG, Woods SE, Krishan M, Genter MB, Pearson KJ. Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. J Nutr. 2011 Apr 1;141(4):582-7.

14. Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR. Role of dietary protein in the sarcopenia of aging. Am J 
Clin Nutr. 2008 May;87(5):1562S-6S.

15. Pepe G, Tenore GC, Mastrocinque R, Stusio P, Campiglia P. Potential anticarcinogenic peptides from bovine milk. J 
Amino Acids. 2013;2013:939804.

16. Markus CR, Olivier B, de Haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the 
sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin 
Nutr. 2002 Jun;75(6):1051-6.

17. Visvanathan R, and Chapman IM. Undernutrition and anorexia in the older person. Gastroenterol Clin North Am. 

18. Ahmed T, and Haboubi N. Assessment and management of nutrition in older people and its importance to health. Clin 
Interv Aging. 2010;5:207-16.

19. Chapman IM. Nutritional disorders in the elderly. Med Clin North Am. 2006;90:887-907.

20. Ahmed N, Mandel R, and Fain MJ. Frailty: An emerging geriatric syndrome. Am J Med. 2007;120:748-53.

21. Heilbronn LK, de Jonge L, Frisard MI, et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic 
adaptation, and oxidative stress in overweight individuals: A randomized controlled trial. JAMA. 2006;295:1539-48.

22. Solerte SB, Gazzaruso C, Bonacasa R, et al. Nutritional supplements with oral amino acid mixtures increases whole- body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol. 2008;101:69E-77E.

23. Nair KS, Short KR. Hormonal and signaling role of branched-chain amino acids. J Nutr. 2005 Jun;135(6 Suppl):1547S- 52S.

24. Lan-Pidhainy X, Wolever TM. The hypoglycemic effect of fat and protein is not attenuated by insulin resistance. Am J Clin Nutr. 2010 Jan;91(1):98-105.

25. Jakubowicz D, Froy O. Biochemical and metabolic mechanisms \by which dietary whey protein may combat obesity and 
type 2 diabetes. J Nutr Biochem. 2013 Jan;24(1):1-5.

26. Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, 
gastrointestinal hormone secretion and appetite. Br J Nutr. 2003;89:239-48.

27. Pal S, Ellis V. The acute effects of four protein meals on insulin, glucose, appetite and energy intake in lean men. Br J 
Nutr. 2010;104:1241-8.

28. Veldhorst MA, Nieuwenhuizen AG, Hochstenbach-Waelen A, et al. Dose-dependent satiating effect of whey relative to casein or soy. Physiol Behav. 2009;96:675-82.

29. Bowen J, Noakes M, Trenerry C, Clifton PM. Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men. J Clin Endocrinol Metab. 2006;91:1477-83.

30. Baer DJ, Stote KS, Paul DR, Harris GK, Rumpler WV, Clevidence BA. Whey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adults. J Nutr. 2011;141:1489-94.

31. Dangin M, Boirie Y, Guillet C, Beaufrere B. Influence of the protein digestion rate on protein turnover in young and elderly subjects. J Nutr. 2002 Oct;132(10):3228S-33S.

32. Doherty TJ. Invited review: Aging and sarcopenia. J Appl Physiol. 2003. 95(4):1717-27.

33. Graf S, Egert S, Heer M. Effects of whey protein supplements on metabolism: evidence from human intervention studies. Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):569-80.

34. Paddon-Jones D, Sheffield-Moore M, Katsanos CS, Zhang XJ, Wolfe RR. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol. 2006 Feb;41 (2):215-9.

35. Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR. Role of dietary protein in the sarcopenia of aging. Am J 
Clin Nutr. 2008 May;87(5):1562S-6S.

36. Koopman R, Verdijk L, Manders RJ, et al. Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr. 2006 Sep;84(3):623-32.

37. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal 
stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E381-7.

38. Fujita S, Volpi E. Amino acids and muscle loss with aging. J Nutr. 2006 Jan;136(1 Suppl):277S-80S.

39. Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr. 2006 Apr;83 (4):735-43.

40. Hack V, Schmid D, Breitkreutz R, et al. Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV/SIV infection, and senescence. FASEB J. 1997 Jan;11(1):84-92.

41. Dillon EL, Basra G, Horstman AM, et al. Cancer cachexia and anabolic interventions: a case report. J Cachexia 
Sarcopenia Muscle. 2012 Dec;3(4):253-63.

42. Bounous G, Baruchel S, Falutz J, Gold P. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest 
Med. 1993 Jun;16(3):204-9

43. Aoe S, Toba Y, Yamamura J, et al. Controlled trial of the effects of milk basic protein (MBP) supplementation on bone 
metabolism in healthy adult women. Biosci Biotechnol Biochem. 2001;65:913-8.

44. Parodi PW. A role for milk proteins and their peptides in cancer prevention. Curr Pharm Des. 2007;13(8):813-28.

45. McIntosh GH, Regester GO, Le Leu RK, Royle PJ, Smithers GW. Dairy proteins protect against dimethylhydrazine- induced intestinal cancers in rats. J Nutr. 1995 Apr;125(4):809-16.

46. Tsuda H, Sekine K, Ushida Y, et al. Milk and dairy products in cancer prevention: focus on bovine lactoferrin. Mutat Res. 2000 Apr;462(2-3):227-33.

47. Zhang X, Beynen AC. Lowering effect of dietary milk-whey protein v. casein on plasma and liver cholesterol concentrations in rats. Br J Nutr. 1993 Jul;70(1):139-46.

48. Meltzer CC, Smith G, DeKosky ST, et al. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology. 1998 Jun;18(6):407-30.

49. Meltzer CC, Price JC, Mathis CA, et al. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology. 2004 Dec;29(12):2258-65.

50. Fernstrom JD, Wurtman RJ. Brain serotonin content: physiological dependence on plasma tryptophan levels. Science. 1971;173:149-52.

51. Fernstrom JD, Wurtman RJ. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science. 1972;178:414-6.

52. Markus CR, Olivier B, Panhuysen GE, et al. The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr. 2000 Jun;71(6): 1536-44.

53. Markus CR, Olivier B, de Haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002 Jun;75(6):1051-6.

54. Camfield DA, Owen L, Scholey AB, Pipingas A, Stough C. Dairy constituents and neurocognitive health in ageing. Br J Nutr. 2011 Jul;106(2):159-74.

55. Chatterton DE, Nguyen DN, Bering SB, Sangild PT. Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns. Int J Biochem Cell Biol. 2013 May 6.

56. Buffinton GD, Doe WF. Depleted mucosal antioxidant defences in inflammatory bowel disease. Free Radic Biol Med. 1995;19:911-8.

57. Duggan C, Stark AR, Auestad N, et al. S. Collier. 2004. Glutamine supplementation in infants with gastrointestinal 
disease: a randomized, placebo-controlled pilot trial. Nutrition.2004;20:752-6.

58. Walzem RL, Dillard CJ, German JB. Whey components: millennia of evolution create functionalities for mammalian 
nutrition: What we know and what we may be overlooking. Crit Rev Food Sci Nutr. 2002;42:353-75.

59. Matsumoto H, Shimokawa Y , Ushida Y , T oida T , Hayasawa H. New biological function of bovine alpha-lactalbumin: 
Protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Biosci Biotechnol Biochem. 2001 

60. Cross M L, Gill HS. Immunomodulatory properties of milk. Brit J Nutr. 2000;84:S81-9.

61. Clare DA, Swaisgood HE. Bioactive milk peptides: A prospectus. J Dairy Sci. 2000;83:1187-95.

62. Bounous G, Kongshavn PA, Gold P. The immunoenhancing property of dietary whey protein concentrate. Clin Invest Med. 1988 August;11(4):271-8.

63. Bounous G, Papenburg R, Kongshavn PA, Gold P, Fleiszer D. Dietary whey protein inhibits the development of dimethylhydrazine induced malignancy. Clin Invest Med. 1988;11(3)213-7.

64. Ford JT, Wong CW, Colditz IG. Effects of dietary protein types on immune responses and levels of infection with Eimeria vermiformis in mice. Immunol Cell Biol 2001;79(1):23-8.

65. Bounous G, Kongshavn PA. Differential effect of dietary protein type on the B-cell and T-cell immune responses in mice. J Nutr. 1985;115(11):1403-8.

66. McCay CM, Crowel MF. Prolonging the life span. Scientific Monthly. 1934 Nov;39(5):405-14.

67. McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate 
body size. Nutrition. 1935;5:155-71.

68. Ward PP, Paz E, Conneely OM. Multifunctional roles of lactoferrin: a critical overview. Cell Molecul Life Sci. 

69. Wakabayashi H, Yamauchi K, Takase M. Inhibitory effects of bovine lactoferrin and lactoferricin B on Enterobacter 
sakazakii. Biocontrol Sci. 2008;13:29-32.

70. Okazaki Y, Kono I, Kuriki TJ, et al. Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in 
rats. Clin Biochem Nutr. 2012 Sep;51(2):84-90.

71. Raghuveer TS, McGuire EM, Martin SM, et al. Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation 
products. Pediatr Res. 2002;52:964-72.

72. Shoji H, Oguchi S, Shinohara K, et al. Effects of iron-unsaturated human lactoferrin on hydrogen peroxide-induced 
oxidative damage in intestinal epithelial cells. Pediatr Res. 2007;61:89-92.

73. Iigo M, Shimamura M, Matsuda E, et al. Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the 
mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine. 2004;25:36- 

74. Oguchi S, Walker WA, Sanderson IR. Iron saturation alters the effect of lactoferrin on the proliferation and differentiation of 
human enterocytes (Caco-2 cells). Biol Neonate. 1995;67:330-9.

75. Spadaro M, Caorsi C, Ceruti P, et al. Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor 
for human dendritic cells. FASEB J. 2008;22:2747-57.

76. Ashida K, Sasaki H, Suzuki YA, Lonnerdal B. Cellular internalization of lactoferrin in intestinal epithelial cells. Biometals. 

77. Garre C, Bianchi-Scarra G, Sirito M, et al. Lactoferrin binding sites and nuclear localization in K562(S) cells. J Cell 
Physiol. 1992;153:477-82.

78. Tung YT, Chen HL, Yen CC, et al. Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation 
and expression of vascular endothelial growth factor. J Dairy Sci. 2013 Apr;96(4):2095-106.

79. Ono T, Murakoshi M, Suzuki N, et al. Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat 
accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated 
lactoferrin tablets. Br J Nutr. 2010 Dec;104(11):1688-95.

80. Salas A, Subirada F, Perez-Enciso M, et al. Plant polyphenol intake alters gene expression in canine leukocytes. J 
Nutrigenet Nutrigenomics. 2009;2(1):43-52.

81. Ruiz PA, Braune A, Holzlwimmer G, Quintanilla-Fend L, Haller D. Quercetin inhibits TNF-induced NF-kappaB transcription 
factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr. 2007 May;137(5):1208- 

82. Dodin S, Cunnane SC, Masse B et al. Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial. Nutrition, Volume 24, Issue 1, January 2008, Pages 23-30. 2008.

83. Faintuch J, Bortolotto LA, Marques PC et al. Systemic inflammation and carotid diameter in obese patients: pilot comparative study with flaxseed powder and cassava powder. Nutr Hosp. 2011 Jan-Feb;26(1):208-13. 2011.

84. Fukumitsu S, Aida K, Shimizu H et al. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. Nutrition Research, Volume 30, Issue 7, July 2010, Pages 441-446. 2010.

85. Hallund J, Tetens I, Bugel S et al. The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women. Nutrition, Metabolism and Cardiovascular Diseases, Volume 18, Issue 7, September 2008, Pages 497-502. 2008.

86. Ibrugger S, Kristensen M, Mikkelsen MS et al. Flaxseed dietary fiber supplements for suppression of appetite and food intake. Appetite, Volume 58, Issue 2, April 2012, Pages 490-495. 2012.

87. Kristensen M, Jensen MG, Aarestrup J et al. Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type. Nutrition & Metabolism 9.1 (2012). 2012.

88. Landete JM. Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health. Food Research International, Volume 46, Issue 1, April 2012, Pages 410-424. 2012.

89. Leyva DR, Zahradka P, Ramjiawan B et al. The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: Rationale and design of the FLAX-PAD randomized controlled trial. Contemporary Clinical Trials, Volume 32, Issue 5, September 2011, Pages 724-730. 2011.

90. Madhusudhan B. Potential Benefits of Flaxseed in Health and Disease - A Perspective. Agriculturae Conspectus Scientificus (ACS) Year: 2009 Vol: 74 Issue: 2 Pages/record No.: 67-72. 2009.

91. Morais D de C, Moraes EA, Dantas MI de S et al. Heat Treatment and Thirty-Day Storage Period Do Not Affect the Stability of Omega-3 Fatty Acid in Brown Flaxseed (Linum Usitatissimum) Whole Flour. Food and Nutrition Sciences 2. 4 (Jun 2011): 281-286. 2011.

92. Moriarty S. Omega-3s from Whole-Food Flaxseed. Cereal Foods World 51. 5 (Sep/Oct 2006): 257-259. 2006.

93. Oomah BD, Der TJ, and Godfrey DV. Thermal characteristics of flaxseed (Linum usitatissimum L.) proteins. Food . Food Chemistry, Volume 98, Issue 4, 2006, Pages 733-741. 2006.

94. Patenaude A, Rodriguez-leyva D, Edel AL et al. Bioavailability of [alpha]-linolenic acid from flaxseed diets as a function of the age of the subject. European Journal of Clinical Nutrition63. 9 (Sep 2009): 1123-9. 2009.

95. Patterson RE. Flaxseed and breast cancer: what should we tell our patients?. J Clin Oncol. 2011 Oct 1;29(28):3723-4. Epub 2011 Sep 6. 2011.

96. Perez-jimenez J, Neveu V, Vos F et al. . Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. European Journal of Clinical Nutrition 64. S3 (Nov 2010): S112-20. 2010.

97. Pruthi S, Thompson SL, Novotny PJ et al. Pilot evaluation of flaxseed for the management of hot flashes. J Soc Integr Oncol 2007; 5(3):106-12. 2007.

98. Rodriguez-Leyva D, Bassett CMC, McCullough R et al. The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. Canadian Journal of Cardiology, Volume 26, Issue 9, November 2010, Pages 489-496. 2010.

99. Sainvitu P, Nott K, Richard G et al. Structure, properties and obtention routes of flaxseed lignan secoisolariciresinol: a review. Biotechnologie, Agronomie, Societe et Environnement 2012, 16(1): 115-124. 2012.

100. Sturgeon SR, Volpe SL, Puleo E et al. Dietary intervention of flaxseed: effect on serum levels of IGF-1, IGF-BP3, and C-peptide. Nutr Cancer. 2011;63(3):376-80. 2011.

101. Tarpila S, Aro A, Salminen I et al. The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone. European Journal of Clinical Nutrition56. 2 (Feb 2002): 157-65. 2002.

102. Taylor CG, Noto AD, Stringer DM et al. Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. J Am Coll Nutr. 2010 Feb;29(1):72-80. 2010.

103. Wu H, Pan A, Yu Z et al. Lifestyle Counseling and Supplementation with Flaxseed or Walnuts Influence the Management of Metabolic Syndrome. The Journal of Nutrition 140. 11 (Nov 2010): 1937-42. 2010.

104. Young R and Ardith B. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutrition Journal Year: 2011 Vol: 10 Issue: 1 Pages/record No.: 44. 2011.

105. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med.1996; 334:1150-5.

106. Albanes D, Heinonen OP, Taylor PR, et al. Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst. 1996; 88:1560-70.

107. Virtamo J, Pietinen P, Huttunen JK, et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA.2003; 290:476-85.

108. Chan GC, Chan WK, Sze DM; "The effects of beta-glucan on human immune and cancer cells." Dept of Paediatrics and Adolescent Med. U of Hong Kong, Hong Kong; J Hematol Oncol 2:25; Pub med 19515245; June 10, 2009: Quote: ...beta-glucans...trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells. As a consequence, both innate and adaptive immune responses can be modulated by beta-glucans and they can also enhance opsonic and non-opsonic phagocytosis [ingestion of foreign matter including cancer cells]. ...They [beta-glucans] are internalized and fragmented within the cells; then transported by the macrophages to the marrow and endothelial reticular system. ...beta-glucans of different sizes and branching patterns may have significantly variable immune potency."

109. Cancer: Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E; "Effects of beta-glucans on the immune system."Medicina (Kaunas).Dept of Physiology, Kaunas U of Medicine, Kaunas, Lithunia. 43(8):597-606; 2007. Quote:"Beta-glucans are naturally occurring polysaccharides....These substances increase host immune defense by activating complement system, enhancing macrophages and natural killer cell function. beta-Glucans also show anticarcinogenic activity. They can prevent oncogenesis due to the protective effect against potent genotoxic carcinogens. As immunostimulating agent, which acts through the activation of macrophages and NK cell cytotoxicity, beta-glucan can inhibit tumor growth...reduce tumor proliferation, prevent tumor metastasis. beta-Glucan as adjuvant to cancer chemotherapy and radiotherapy demonstrated the positive role in the restoration of hematopiesis [red blood cells] following by bone marrow injury. Immunotherapy using monoclonal antibodies is a novel strategy of cancer treatment. These [monoclonal] antibodies activate complement system and opsonize tumor cells with iC3b fragment. ...tumor cells, as well as other host cells, lack beta-glucan as a surface component and cannot trigger complement receptor 3-dependent cellular cytotoxicity and initiate tumor-killing activity. This mechanism [tumor-killing activity] could be induced in the presence of beta-glucans.

110. Diabetes / Glucose Controlr: Pola P, "Composition for the prevention and/or treatment of lipid metabolism disorders and allergic forms," U.S. Patent Application 20030017999, January 23, 2003. ".beta-1,3-D-glucan has proved effective not only in preventing lipid metabolism disorders, but also in stimulating immune defenses, in preventing onset of tumors and in controlling serum glucose.

111. Diabetes: Carrow, D.J.; "Beta-1,3-glucan as a Primary Immune Activator," Townsend Letter; June 1996. Quote: "The following list includes benefits from the use of Beta 1,3-glucan supplementation: …people with chronic degenerative disorders such as diabetes or chronic inflammation. …

112. Tumors: Brown G D, Gordon S; "Immune recognition. A new receptor for beta-glucans." Sir William Dunn School of Pathology, University of Oxford, Nature 6;413(6851):36-7. Sep 2001. Quote:"The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them."

113. Schwitters B, Masquelier J. OPC in Practice: Bioflavanols and their Applications. Rome, Italy: Alfa Omega; 1993.

114. Masquelier J, Dumon MC, Dumas J. Stabilization of collagen by procyanidolic oligomers [in French; English abstract]. Acta Ther. 1981;7:101-105.

115. Tixier JM, Godeau G, Robert AM, et al. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases. Biochem Pharmacol. 1984;33:3933-3939.

116. Maffei Facino R, Carini M, Aldini G, et al. Free radical scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera .A mechanism for their capillary protective action.Arzneimittelforschung. 1994;44:592-601.

117. Masquelier J, Dumon MC, Dumas J. Stabilization of collagen by procyanidolic oligomers [in French; English abstract]. Acta Ther. 1981;7:101-105.

118. Pecking A, Desprez-Curely JP, Megret G. Oligomeric grape flavanols (Endotelon) in the treatment of secondary upper limb lymphedemas [translated from French]. Study on file with manufacturer, International Nutrition Company (INC),Vaduz, Liechtenstein. 1989;69-73.

119. Maffei Facino R, Carini M, Aldini G, et al. Free radical scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera .A mechanism for their capillary protective action.Arzneimittelforschung. 1994;44:592-601.

120. Preuss HG, Wallerstedt D, Talpur N, et al. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med. 2000;31:227-246.

121. Masquelier J, Dumon MC, Dumas J. Stabilization of collagen by procyanidolic oligomers [in French; English abstract]. Acta Ther. 1981;7:101-105.

122. Bagchi D, Garg A, Krohn RL, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol. 1997;95:179-189.

123. Thebaut JF, Thebaut P, Vin F. Study of Endotelon in functional manifestations of peripheral venous insufficiency [translated from French]. Gaz Med. 1985;92:96-100.

124. Schwitters B, Masquelier J. OPC in Practice: Bioflavanols and their Applications. Rome, Italy: Alfa Omega; 1993.

125.* Christie S, Walker AF, Hicks SM, et al. Flavonoid supplement improves leg health and reduces fluid retention in pre-menopausal women in a double-blind, placebo-controlled study. Phytomedicine. 2004;11:11-17.

126. Erdman JW Jr, Balentine D, Arab L, Beecher G, Dwyer JT, Folts J, Harnley J, Hollman
P, Keen CL, et al. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr. 2007;137(3 Suppl 1):S718–37. Abstract/FREE Full Text

127. Gómez-Pinilla et al. Brain foods: the effects of nutrients on brain function. Nature Reviews Neuroscience, 2008; 9 (7): 568 DOI: 10.1038/nrn2421

128. Bourre JM. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2: macronutrients. J Nutr Health Aging. 2006 Sep;10(5):386-99.

129. Bruinsma KA, Taren DL. Dieting, essential fatty acid intake, and depression. Nutr Rev. 2000 Apr;58(4):98-108.

130. Conklin SM, Manuck SB, Yao JK, Hibbeln JR, Flory JD, Muldoon MF. Serum phospholipid polyunsaturated fatty acids are associated with mood, behavior and personality in healthy community adults. American Psychosomatic Society annual meeting, March 2007, Budapest, Hungary, abstract 1718.

131. Osher Y, Belmaker RH, Nemets B. Clinical trials of PUFAs in depression: State of the art. World J Biol Psychiatry. 2006;7(4):223-30.

132. Van der Beek EJ, van Dokkum W, Wedel M, Schrijver J, van den Berg H. Thiamin, riboflavin and vitamin B6:impact of restricted intake on physical performance in man. J Am Coll Nutr 1994;13:629–40. Medline

133. Wozenski, J.R., Leklen, J.E. & Miller, L.T. 1980. The metabolism of small doses of vitamin B6 in men.J. Nutr., 110: 275-85.

134. Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2010;7:e1000252.

135. Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med. 2011;364:2392-404.

136. Pinilla FG. The impact of diet and exercise on brain plasticity and disease. Nutr Health. 2006;18(3):277-84.

137. Riserus U, Willett WC, Hu FB. Dietary fats and prevention of type 2 diabetes. Prog Lipid Res. 2009;48:44-.

138. Hu F, Manson J, Willett W. Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr. 2001;20:5-19.

139. Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women.Circulation. 2009;119:1093-100.

140. Kushi L, Giovannucci E. Dietary fat and cancer. Am J Med. 2002;113 Suppl 9B:63S-70S.

141. World Cancer Research Fund, American Institute for Cancer Research. Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective – Online. 2007. Accessed January 11, 2012.

142. Hodge W, Schachter H, Barnes D, et al. Efficacy of omega-3 fatty acids in preventing age-related macular degeneration: a systematic review. Ophthalmology. 2006;113:1165-72.

143. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG: Carotenoids in the human macula and whole retina. 
Invest Ophthalmol Vis Sci 1988, 29:850-5.

144. Kirschfeld K: Carotenoid pigments: their possible role in protecting against photooxidation in eyes and photoreceptor cells.Proc R Soc Lond 1982, 216:71-85.

145. Snodderly DM: Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. 
Am J Clin Nutr 1995, 62(suppl):1448s-60s.

146. Pratt S: Dietary prevention of age-related macular degeneration. 
J Am Optom Assoc 1999, 70:39-47. 

147. Jaques PF: The potential preventive effects of vitamins for cataract and age-related macular degeneration. 
Int J Vitam Nutr Res 1999, 69:198-205.

148. Berendschot TTJM, Goldbohm RA, Klopping WAA, van Norel J, van Norren D: Influence of lutein supplementation on macular pigment, assessed with two objective techniques. 
Invest Ophthalmol Vis Sci 2000, 41:3322-6.

149. Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC. Increased stress response and β-phenylethylamine in MAOB-deficient mice. Nat Genetics. 1997;17:206–210. doi: 10.1038/ng1097-206.

150. Sabelli H, Fink P, Fawcett J, Tom C. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8:168–171.